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Información Saber Vivir
Enviado por: Taroteca - 3 horas - Foro: Tarot en Barcelona - videntes buenas de Bcn y tarotistas - Sin respuestas

La vida es una aventura dónde todos participamos.Nuestro destino es sólo nuestro y en él existen momentos y personas maravillosas.Porque la vida es tu aventura para aprender y sentir.944079331 Pago mediante tarjeta de crédito: 15 minutos 12 euros 30 minutos 20 euros 60 minutos 35 euros.Tarot De La Evolución.

[Imagen: reacci10.jpg]


  What Is Difference Between APIs And Intermediates?
Enviado por: Pieere001 - Ayer, 08:31 AM - Foro: Foros de amarres de amor, opiniones gratis y testimonios experiencias - Sin respuestas

What are pharmaceutical intermediates?
Pharmaceutical intermediates are fine chemicals that are intermediate compounds produced during the production of active pharmaceutical ingredients (APIs). Intermediates are the by-products of the reactions in the API production process. Each reaction in the production process may produce several intermediates, depending on the analysis, which can be used as precursors for other active pharmaceutical ingredients. The conversion of intermediates to active ingredients can be achieved by further refinement processes. Like APIs, intermediates can also be used as APIs for therapeutic purposes.

4-Chloro-2,6-diaminopyrimidine CAS No.: 156-83-2 is used as an intermediate of the drug Minoxidil, also used in organically synthesized compounds. α-Lipoic Acid CAS No.: 1077-28-7 is used as an intermediate of vitamin drugs, can stimulate fat metabolism. It is used for the treatment of acute and chronic hepatitis, liver cirrhosis, hepatic coma, fatty liver, diabetes, and other diseases.

What are APIs in pharmaceuticals?
API (Active Pharmaceutical Ingredient) refers to the active ingredient contained in a drug. For example, a painkiller contains an active ingredient that relieves pain. A small amount of the active ingredient has an effect, so the drug contains only a very small amount of the active ingredient. You can find the name and quantity of the active ingredient in medicine on the packaging of OTC (over-the-counter) medicines lincomycin hydrochloride.
How APIs are made?
API and raw material are often confused due to the similar usage of these two terms. What is the difference? The raw material is a compound that is used as the basis for making an API. an API is not made from raw material by just one reaction, but by a variety of compounds that become API. the compounds that are being transformed from raw materials into APIs are called intermediates. Some APIs go through more than ten intermediates in the process of going from raw material to API.
The difference between APIs and intermediates
What is the difference between an API and a pharmaceutical intermediate? These terms can be confusing and used interchangeably, especially by those new to the pharmaceutical industry. Although both APIs and intermediates have pharmacological activity, they differ in function, composition, and structure.
What are the key differences between APIs and intermediates?
Many factors and analyses distinguish active ingredients and compounds from pharmaceutical intermediates. Active ingredients and specialty chemicals are the end products of raw materials, while chemical intermediates are by-products of the API manufacturing process. Unlike APIs, which are usually safe and properly studied for therapeutic purposes, intermediates may be therapeutic, toxic, or even APIs. however, APIs produced as by-products cannot be administered or used as active ingredients without official approval. In addition, unlike active ingredients containing special chemicals, intermediates do not require approval or regulation to be used.
Innovation in pharmaceutical intermediates butazolidine.
The pharmaceutical industry is constantly evolving and reinventing itself. Maxmedchem Corporation and market players are adapting to innovations in the sale of pharmaceutical intermediates, as the demand for them is increasing rapidly. The growth in demand is the result of a combination of factors such as the surge in chronic diseases, which is having a positive impact on the size of the global pharmaceutical intermediates market. As global pharmaceutical activity increases, innovations are being born and demand for pharmaceutical intermediates manufacturers is on the rise. The global pharmaceuticals and packaging market has experienced a surge due to the implementation of regulated pharmaceutical activities, Good Manufacturing Practices (GMP) by pharmaceutical companies.


  Vitamins B benefits
Enviado por: Pieere001 - Ayer, 08:07 AM - Foro: Echadoras de cartas - Sin respuestas

B complex vitamins usually deliver eight of the B vitamins: B1 (thiamin), B2 (riboflavin), B3 (niacin), B5 (pantothenic acid), B6 (pyridoxine), B7 (biotin), B9 (folate), and B12 (cobalamin). Found naturally in meat, leafy greens, dairy, beans, peas, and whole or fortified grains, B complex vitamins are water-soluble and play an essential role in certain bodily functions including helping your body make energy from the food you eat and forming red blood cells.

benefits of B vitamins
Verywell / Joshua Seong
Health Benefits
Each of the eight vitamins in vitamin B complex supplements comes with its own unique set of health benefits. For instance, vitamin B1 is critical for the growth, development, and function of cells in the body. Other vitamins, such as B2, work cooperatively in the body with other B vitamins to convert food into energy. B2 converts B6 into a usable form and aids in niacin production.1

Vitamin B5 breaks down fats and carbohydrates for energy and helps the body use other vitamins, such as riboflavin (found in B2). B6 is involved in immune function and needed by the body to use and store protein and carbohydrates from food in the form of glycogen.2

B7 also helps the body convert the fats, carbohydrates, and proteins in the food you eat into energy. It is needed to make fatty acids and also maintains bone and hair health. Vitamin B9 is required to help cells produce and maintain DNA (the genetic material found in all body cells), while Vitamin B12 powder is important for protein metabolism.34

Not everyone requires vitamin B supplementation. Depending on your individual needs and recommendations from your doctor, you may be advised to take a specific B vitamin supplement alone over a B-complex supplement.

Converts Food Into Energy
Most of the B vitamins are involved in the process of converting food into energy. Some help metabolize carbohydrates, while others break down fat5 and/or protein.6

While this is an essential process, it is not necessarily the case that taking a B-complex supplement will make you feel more energetic. Although your body needs B vitamins to create energy from the foods you eat, the effect is different when these vitamins are consumed in the form of dietary supplements rather than food.

B vitamins involved: B1, B2, B3, B5, B6, B7, and B12

Supports Brain Health
Research shows that B vitamins support just about every aspect of brain health. While all B vitamins promote healthy brain function, a 2016 review published in Nutrients indicates that vitamins B6, B9, and B12 play a particular role in homocysteine metabolism, which helps reduce the risk of cognitive decline and dementia.7 In particular, B12 supports healthy DNA structures, which are important during fetal development and the prevention of chronic disease and cancer.8

Vitamin B6 supports both brain development and function,2 while vitamin B9 reduces the risk of birth defects in the brain and spine, such as spina bifida.3

B vitamins involved: B1, B2, B3, B5, B6, B7, B9, B12

Produces Red Blood Cells
Some B vitamins, particularly vitamin B12, play an essential role in red blood cell formation. Healthy red blood cells are needed to transport oxygen to every part of the body. When there is a vitamin B12 deficiency, the body cannot produce enough red blood cells and anemia can occur.9

Vitamin B2 is also needed for red blood cell production and growth, as is vitamin B9. While vitamin B5 plays a role in red blood cell production, it also helps reduce the amount of cholesterol produced by the body. And vitamin B6, which is required for more than 100 different enzyme reactions in the body, aids in the formation of hemoglobin, which also allows red blood cells to carry oxygen through the blood.10

B vitamins involved: B2, B5, B6, B9, B12

Promotes Nervous System Health
Vitamin B2 powder keeps the eyes, nervous system, and skin healthy. It aids in the conversion of food into energy and helps enzymes in the body function properly. It also makes and repairs DNA,1 helps with the optimal function of the digestive and nervous systems, and promotes skin health. In addition, vitamin B12 also plays a role in maintaining the health of the nervous system.11

B vitamins involved: B1, B2, B3, B6, B12

Supports Hormone Production
pharma grade Vitamins B3 and B5 are needed for the production of hormones in the adrenal glands, such as sex and stress hormones.512 Vitamin B6 stimulates neurotransmitters and hormones that influence mood and regulate the body's biological clock.

B vitamins involved: B3, B5, B6


  Dinoplativolos la serie de tu infancia.
Enviado por: unamigocerrajero - 19-01-2022, 05:42 PM - Foro: Tarot en Albacete - videntes buenas de Albacete y tarotistas - Sin respuestas

El cine relaja y reduce la ansiedad y el estrés. Cuando vemos una película, nos “olvidamos” durante un rato del resto del mundo para concentrarnos solo en lo que ocurre en la pantalla. A diferencia de la lectura, que es un proceso más activo, disfrutar del cine es una actividad pasiva: es mucho más fácil distenderse, desconectar, darse un descanso mental.

Pero muchas personas no son amantes de desplazarse hasta un cinema para ver una película, por eso existen muchas opciones online para ver otro tipo de contenido de forma online como Series Retro como los dino plativolos.


  Muebles de jardín
Enviado por: alfre123do - 19-01-2022, 01:27 PM - Foro: Tarot - Sin respuestas

No me complico cuando toca remodelar un poco las cosas en el hogar, sobre todo por comodidad, hace poco nos mudamos mi pareja y yo, ahora tenemos un jardín un poco más grande, por eso decidimos también renovar algunas cosas. Pues nos topamos con una excelente sitio de Muebles de jardin maravillosos, nos investigamos un poco las opciones y nos gustaron unos para poder colocar, también acompañados de unas plantas de exterior, pues quedo genial. Lo recomiendo siempre, hacer pequeños cambios en casa que den una nueva vibra.


  Publicar un libro
Enviado por: alfre123do - 19-01-2022, 01:24 PM - Foro: Tarot - Sin respuestas

Saludos, espero estén bien todos por aquí. Desde hace un buen rato, con el tema del encierro y un poquito de tiempo libre que mee quedaba luego del trabajo, retome algo que me gustaba hace un tiempo ya, se trata de un libro que quería escribir y que tenía una buena idea, sobre todo inspiradora de parte de mi vida. Lo había abandonado hace ya rato, pero lo retome, lo termine y también mejore un poco lo que ya había escrito anteriormente, solo necesitaba saber algo, y era aprender a publicar libro en amazon, por suerte me tope con un buen tutorial y consejos en la web de pabloyglesias, espero que si están en lo mismo, sobre todo si no son expertos en estos temas de publicar libros, se lean mucho las opciones que tienen y pues tengan suerte con todo este proceso. Éxitos y a llevar a cabo esos proyectos que están por terminar.


  Contar con sofás
Enviado por: alfre123do - 19-01-2022, 01:19 PM - Foro: Tarot - Sin respuestas

Saludos amigos del foro. No hay nada más importante que llegar a tu hogar tras un día intenso y tener un buen espacio cómodo para desconectar. Tanto los sillones como los sofás son muebles muy funcionales. No solo sirven de asiento, sino que aportan gran comodidad, confort, relajación y son beneficiosos para la salud. Sin duda alguna contar con sofás en el hogar es muy valioso en todos los sentidos posibles, y es muy crucial contar con uno. Si por alguna razón buscas un lugar, les comparto la web de Sofás Sofassimo, para que tengan un sitio la cual visitar.


  M&A between API and Formulation firms could lead to profitable consolidation?
Enviado por: Pieere001 - 17-01-2022, 04:25 AM - Foro: Foros de amarres de amor, opiniones gratis y testimonios experiencias - Respuestas (1)

Big pharma companies are experiencing the so called "patent cliff" for sometime now.

As blockbuster drugs are going off patent protection, companies find it tough to push through new patented drugs in the market at a faster pace. This brings in cost as well as competitive pressures. And the latest wave of pharma consolidation acts as a counterpoint to these looming challenges.

Pharma value chain can be broadly divided into two categories: Active Pharmaceutical Ingredients (API) and Finished Formulation.

APIs denote the dosage in a drug, or in other words the key chemicals that make the drug work, while finished formulation is the process in which different chemicals, including the active ingredient, are mixed in specified ratios to produce a specific drug.

For their part, the suppliers thus far have stayed true to their strength areas. For example, a supplier specializing in formulation will do only formulation. The one specializing in Active Pharmaceutical Ingredients (API) will not look anywhere beyond their core area.

Spinoza believed that all things wish to go on being what they are: a stone wishes eternally to be a stone while a tiger would always want to be a tiger.
However, in the rapidly evolving supplier markets, not all formulation and API firms can wish to forever continue doing what they have been doing. A few of them, if not all, would have to look to buy into other areas.

Of course, the suppliers have understood this conundrum very well and have started moving towards "cross consolidation". In other words, API firms, including maxmedchem corporation have started buying up formulation companies and vice versa.

For example, in 2013, speciality API manufacturer AMRI bought OSO bio pharma and Cedarburg Hauser to expand its footprint in injectable formulations.
In 2014, Patheon, a leading formulation service provider, partnered with DSM Pharmaceutical Products to form a separate entity known as DPx, which is now a fully integrated provider of APIs and formulations, including levocetirizine dihydrochloride.

How much of an impact do these mergers create in the supply market? Not much in reality as the market is very fragmented and no group of players have dominating market share.

When times are tough, or even if it is anticipated to get tough in the future, category managers will be asked to trim the supply base so as to save on expenses. But is it easier said than done?

Also, from the point of view of supplier management, do such deals offer benefits for buyers i.e, pharma companies 2-6-pyridinedicarboxylic acid ?

"Yes," says Owais Shah and Pradeep Kasirajan, Beroe's pharma industry experts.

During the webinar scheduled for July 23, Shah and Kasirajan will explain how consolidation between API and formulation companies can help big pharma companies in reducing their supplier base.

To take part in the discussion please click here:

Below table lists out some of the major deals that had happened between API and formulation suppliers.

Key Takeaways:

What is API and formulation in pharma? API and Finished Formulations are two subcategories of pharma’s value chain and the difference between API and formulations is what they do.

API stands for Active Pharmaceutical Ingredient and it specifies the active ingredients in the drug. Finished formulation is the method used to mix ingredients to make a particular drug.

A big pharma company generally deals with about 200 to 250 suppliers of API formulation all over the globe.

Dealing with so many suppliers brings its own set of challenges for big pharma companies such as costs and business trail.

Due to the difference between API and formulation each supplier used to only specialize in either API or formulation. This is what Spinoza believed too.

Supplier markets continue to evolve at a rapid rate and there have been significant changes in the way formulation vs API suppliers work.

Despite the difference between formulation and API, cross consolidation is well underway as some API companies are buying finished formulation companies and vice versa.

API and finished formulation companies do not wish to continue to be best in only one task like before despite the API and pharmaceutical intermediates difference.

AMRI purchased OsoBio Pharma in 2013 and Cedarburg Hauser so it can go forward and become a leader in injectable formulations.

Patheon was a formulation company and in 2014 it merged with DSM Pharmaceutical Products to form DPx. DPx provides formulations and APIs now.

The pharma market is highly fragmented and so the mergers between API companies and formulation companies that produce lincomycin hydrochloride aren’t as impactful at present in terms of the supply market.

There aren’t many big players who dominate the market either so the consolidation won’t be as significant.

The difference between API and formulation in pharma might stay as not all companies will turn to cross consolidations and will continue to do what they have always been doing.

If big pharma companies want to save on expenditure to curb overspending, then they might need to lessen the number of suppliers they work with. This might be a necessity in case of difficult times.

Big pharma companies will benefit from consolidations between APIs and formulation companies from the perspective of supply management as they won’t have to deal with multiple suppliers like before.

Big pharma firms will always have a wide range of options to choose from whether other companies opt for cross consolidations or not.

Maxmedchem Corporation, was founded in 2004 .We offer the following services, like Contract Development and Manufacturing, and OEM business of APIs and intermediates, vitamins and minerals.we have the most professional service team, research team and could provide a rapid and accurate response to a variety of clients’ demands in unique synthetic design, manufacturing process, and commercial manufacturing.


  Pedicura verano
Enviado por: lozina - 16-01-2022, 12:10 PM - Foro: Avisos - Sin respuestas

Pedicura verano
Pedicura blanca de verano.
Además de los tonos brillantes, el Revestimiento de laca blanca se usa a menudo en verano. Este color armoniza perfectamente con los pedrería, que se aplican en forma de tiras, agujeros, formas geométricas o coronas. Será bastante interesante verse si se aplica un fondo blanco con un pincel con una dispersión de migas brillantes. Esta decoración decorará perfectamente la uña del pulgar. Todas las demás caléndulas se pueden pintar completamente en un estilo brillante.
El pedicure para verano adquiere un significado especial para los meses más cálidos, porque es el momento de las sandalias y las chanclas.
Pedicura en el estilo de verano "sweet bloom"
Este diseño es una tendencia caliente. El increíble diseño de Sweet Bloom es perfecto para cualquier ocasión especial. Cualquier belleza, después de decorar sus caléndulas de piernas elegantes en este diseño, adquirirá un aspecto aún más exquisito y único. La espectacularidad y el brillo de la pedicura darán patrones y estampados florales.
Manicura de verano con frutas.
La cálida temporada de verano es un momento maravilloso para saborear frutas jugosas. Los maestros han utilizado durante varios años consecutivos como decoración de caléndulas femeninas, son los elementos de la fruta. Las frutas exóticas y la abundancia de "deliciosos" se ven muy bien en la pedicura de verano. Esta decoración sirve mejor como decoración del pulgar. Así es como los estilistas modernos creen.
A su atención se ofrecen las opciones más interesantes de la pedicura de verano, que se consideran populares. Esperamos que después de Leer este material, pueda elegir fácilmente el diseño de pedicura deseado, que complementará un vestido de verano ligero o un traje de baño sexy. ¡Lo más importante es que no tengas miedo de experimentar con tu imagen!
[Imagen: light-blue-avocado-pedicure-for-women.webp]


  Marketing Outsourcing
Enviado por: alfre123do - 14-01-2022, 05:15 PM - Foro: Tarot - Sin respuestas

Saludos amigos del foro. ¿Has oído hablar del Marketing Outsourcing? Se trata de una fórmula con innumerables ventajas que todavía muchas empresas desconocen. En este momento, con la inestabilidad producida por el confinamiento, muchas empresas industriales y tecnológicas se preguntan cómo potenciar sus resultados de marketing y ayudar al equipo comercial. El Marketing Outsourcing es la externalización del departamento de marketing de una empresa a otra, generalmente a una agencia especializada, que gestiona la estrategia y ejecuta las diversas acciones integradas.


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